Sergio Romero, who deputised for De Gea at Southampton and saved a penalty in that match, will start ahead of the Spain global in next Wednesday's Europa League final against Ajax.
Manchester United have left David de Gea out of their matchday squad for their latest Premier League clash with Southampton.
Hit play on the video at the top of the page to watch highlights from the match.
United manager Jose Mourinho has confirmed Romero will start against Ajax in Stockholm next Wednesday and his early save from Manolo Gabbiadini helped the visitors stop the rot after successive losses to Arsenal and Tottenham Hotspur.
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With the Europa League final providing a path into next season's Champions League the game could define whether Mourinho's season at United can be regarded as a success or failure. I hope you don't kill me when you see my team. I enjoy the second because in the second I know I'm not making mistakes.
"Fellaini, on top of his experience, he says it's not a tear", Mourinho told the club's website.
Allardyce said that the English football authorities could have easily brought the game forward and that it's a shame that England are not like other countries who he claimed would "bend over in fixture terms to help their teams win European competitions". "They showed they want to be in that final". I never saw that with Chelsea, with United, with Man City previous year.
"I don't go with [Romero can replace De Gea] "if he leaves" because I hope he doesn't", Mourinho said.
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Mourinho said the likes of Demetri Mitchell, Scott McTominay, Axel Tuanzebe, Matthew Willock, Josh Harrop and Zachary Dearnley would join Eric Bailly and Paul Pogba in the matchday squad.
But United were already guaranteed to finish sixth, while Southampton, who have not scored in four successive top-flight home games for the first time, remain eighth.
Southampton manager Claude Puel refused to discuss his future at the club, which is the subject of speculation.
"I try to stay focused about our last game now", he said.
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"Any teams have a debrief at the end of the season and this is normal but the end of the season is after the last game and the last game is very important".