By effectively forfeiting the race for a top-four finish and putting all his eggs into the Europa League basket, the United manager has ramped up the pressure on his players.
"I think after the moment Crystal Palace beat Hull City [last Sunday] and Hull City is relegated and Swansea is safe - in that moment, our match has to be Saturday".
Midfielder Marouane Fellaini is doubtful for United's last league game and next week's Europa League final after sustaining an injury yesterday.
"I never saw that with Chelsea, I never saw that with Manchester United, I never saw that with Manchester City previous year".
"The good thing is the club knows, the board knows, I know and we are together on this process".
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The Portuguese is focusing on next Wednesday's Europa League final against Dutch side Ajax and is set to field a youthful team for the largely meaningless final game of the Premier League season.
Manchester United play host to Crystal Palace as the curtain comes down on the Premier League season this weekend.
Asked when De Gea might be seen in a United shirt again, Mourinho said: "The first match against LA Galaxy in preseason in Los Angeles".
Manchester United have stepped up their interest in Atletico Madrid goalkeeper Jan Oblak amid concerns that David De Gea will push through a summer move to Real Madrid, sources have told ESPN FC. "We have to accept the way it is".
"We will play our 56th game next Wednesday and if you look at the age of the players we have, then it is a really young team who have also played a lot of games", said Bosz.
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"I hope he tells Wilfried Zaha to go slow and leaves Christian Benteke at home".
Midfielders Willock and Mitchell have been unused substitutes in recent weeks and will be joined in the team by Scott McTominay, who made his maiden senior appearance against Arsenal, Harrop and teenager Dearnley.
I don't blame myself or our decision.
"Fosu-Mensah plays Sunday [against Crystal Palace] and if the reaction is good and he plays without problems, he is a new option for us for the final".
'We only train with 23 players but now no one injured so instead of looking at United I look at my team'.
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"Any teams have a debrief at the end of the season and this is normal but the end of the season is after the last game and the last game is very important". There are clubs with more stability than us, better squads, more time to work.