He'll have to stay healthy for that, however, as Ibrahimovic is a key part of Mourinho's team.
We're accustomed to seeing Marcus Rashford grab the headlines in dramatic fashion - very few footballers announced themselves to the world in the way that the England worldwide did last season - but despite his reputation for heroics, Manchester United fans were left with no doubt about who their saviour was yet again.
Pogba also almost scored the goal of the season, with his overhead kick from a Rashford "rabona" cross blocked on its way towards the Anderlecht goal. Yet the teenager was hardly alone there.
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Marcos Rojo was stretchered off in the first half, which was a serious blow on its own.
Rojo had twisted a knee going for a tackle and having received some lengthy treatment, tried to continue before it became obvious in the next challenge that he was in no state to carry on.
The 31-year-old captain has not played since April 1 due to ankle pain but will be assessed by Jose Mourinho on Wednesday afternoon with a view to being on the bench.
Zlatan was poor on the night but has been sensational for Manchester United and this injury could well play a big role in where the super Swedish striker plays his football next season.
"I think it's time for Jones and Smalling to be courageous, to risk", said the Portuguese, whose side visit Burnley in the Premier League on Sunday before tackling Manchester City next Thursday.
Nine minutes after the substitution, United's opponents had the ball in a promising position on the right.
But Reuben Martinez made two excellent saves and Anderlecht then hauled themselves into the game; as such, it was no great surprise when Sofiane Hanni equalised, ramming home after good work from Youri Tielemans.
"We played very well in the first half". Pogba's pass to Rashford in the build-up to the opening goal, 10 minutes in, was a particular joy, beautifully weighted over 40 yards.
Rashford's cross was blocked, but the ball came back to him and he squared it for Mkhitaryan, who drilled a low shot into the bottom-left corner.