Duje Cop opened the scoring with a well-taken volley from close range before a super Isco equaliser into the top corner of the Sporting net.
Isco has only played 77 minutes for Real Madrid in the Champions League across two appearances, but after he stood head and shoulders above his team mates in Gijon, he may be rewarded with a start against Bayern Munich on Tuesday.
During their meeting, Isco learnt how to say "I love you" in sign language, and the Madrid star paid homage to the awesome fans after finding the target.
Madrid twice fought back from a goal down against the relegation-threatened side at the Santiago Bernabeu on Saturday, before Isco's 90th-minute victor kept them on track for a first league title since 2012.
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The former Valencia midfielder is entering the final year of his current deal which has caught the attention of several potential suitors, but he has hinted that he could sign an extension with Real Madrid provided he is guaranteed more playing time.
Mariano Diaz was introduced 20 minutes from time as Zidane looked to complete the turnaround, and a low Marcelo strike was deflected just wide of the post in the 72nd minute as Sporting came under a siege of pressure. They need to start winning soon if they're going to avoid the drop, but getting points off Real may be too big of an ask.
The hosts took advantage, showing no fear against the league leaders and they broke the deadlock with Cop's well-worked goal.
The 24-year-old has constantly been linked with a move away from the club, but Zidane wants to keep him at the club.
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But Alvaro Morata headed Madrid level again in the 59th from a pass by Danilo, and the pacesetters kept pushing until Isco netted the victor.
He said: "Zidane makes the line-ups and is managing the squad in an extraordinary way". It has won just five times in 31 rounds this season, and has scored one goal in its last three games. He nearly scored in the first minutes of the second half but Cuéllar prevented it with a great save.
The visit to Gijon may feel like an easy trip and a secondary event with Bayern and Barcelona on the horizon, but Real Madrid will find a fighting Sporting ready to pounce if they show any weaknesses. Credit must be given where due to the Osasuna goalkeeper, Salvatore Sirigu, who is on loan from PSG, judged both the penalties (from Carrasco and Thomas Partey) correctly, and stopped Carrasco's hat-trick and further humiliation to team.
"We know that with the team we have we can do damage to any team and fighting to the end to get three points is in our DNA at Real Madrid".
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